At Bozeman Sports Medicine, we offer many advanced medical treatments to help you recover in record time in the least invasive way.
Alpha-2-macroglobulin (α2-M or A2M)
A2M is a remarkable substance that has ample evidence for its effectiveness in the treatment of osteoarthritis (OA) and degenerative musculoskeletal conditions, like tendinosis and tendon tears. We now know that a major culprit in these diseases is enzymes (proteases) that destroy structural proteins such as collagen, leading to breakdown of cartilage, tendons, ligaments and bone. A 1999 study showed that in chronic wounds, proteases are present in abundance and are responsible for failure to heal.1 In short, proteases in high concentrations, which is a typical scenario for chronic tissue damage and joint disease, is bad. A2M binds these enzymes in a manner similar to a venus fly trap and carries them away for disposal, making it an ideal substance for stopping disease processes in OA, chronic non-healing injuries, and tendon or ligament disorders.2 The goal in treatment is not to suppress symptoms, but rather to stop tissue destruction. This represents a major departure from standard approaches, which use pain medications and cortisone, none of which are disease modifying.
A2M is a game changer in the treatment of musculoskeletal conditions
We obtain A2M in a concentrated form, 80 to 100 times baseline concentration, from your blood plasma, using an FDA-compliant sterile device. Using precise ultrasound guidance, the A2M is delivered to the location of the disease, whether it be a joint, an area of degenerated and torn tendon, or a damaged ligament. Platelet-rich plasma (PRP) is injected with the A2M, to provide growth factors for healing. We have seen that improvement using A2M plus PRP is substantially faster than with PRP alone or with PRP and lipoaspirate (your own fat). As a result, activity and sports downtime is reduced, return to play quicker, and pain relief occurs sooner. With ultrasound, we see restoration of the integrity of tendons and ligaments within weeks.
Some of the destructive enzymes that A2M traps include:
Dr. Adams was the senior researcher on a study of osteoarthritis in Montana ranchers, which demonstrated a correlation between worse joint symptoms during calving season and elevated MMP-1 levels. The study also found that ranchers with a higher body mass index had higher MMP-3 levels.6
If we are treating damage to a tendon or a ligament, the repair is permanent. For chronic inflammatory conditions like osteoarthritis, typically two years.
The pain relief in knee osteoarthritis (OA) with A2M is impressive. A2M traps and removes the proteases that are causing the damage in OA. We have found the pain relief to be superior to and longer lasting than PRP alone or hyaluronic acid (Supartz, Synvisc, Orthovisc, etc.). It is far longer lasting than cortisone, and unlike cortisone, is disease modifying.
In knee osteoarthritis, pain relief occurs in less than a week and improves steadily for the next few weeks thereafter.
Since we are injecting PRP at the same time, do not take anything that impairs platelet function (NSAIDs (ibuprofen, naproxen, Orudis, etc.), aspirin, tumeric). Smokers should avoid smoking for at least a month beforehand